Mouse models of chronic wasting disease: A review

Animal models are essential tools for investigating and understanding complex prion diseases like chronic wasting disease (CWD), an infectious of cervids (elk, deer, moose, reindeer). Over the past several decades, numerous mouse have been generated to aid in advancement CWD knowledge comprehension. These facilitated investigation pathogenesis, transmission, potential therapies CWD. Findings impacted management outcomes, though much remains unknown, a cure has yet be discovered. Studying wildlife effects is singularly difficult due long incubation time, subtle clinical signs at early stages, lack convenient in-the-field live testing methods, reproducibility controlled laboratory setting. Mouse many cases first step mechanisms shortened time frame. Here, we provide comprehensive review studies with research. We begin by reviewing that examined use bioassays tissues, bodily fluids, excreta spread disease, then address routes infectivity load. Next, delve into genetic factors influence protein structure. move on immune factors, possible transmission through environmental contamination, species barriers differing strains. conclude make cervidized search